Orochem RubyPro Protein Crash and Precipitation Filter Protein Crash and Precipitation Filter 96 Well Plate/ 1 mL 2 PK

CAD $ 781.81

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Overview

SKU

OMNPPT20-5

Overview

Orochem RubyPro Protein Crash and Precipitation Filter Protein Crash and Precipitation Filter 96 Well Plate/ 1 mL 2 PK

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Overview

Protein precipitation is a common protocol for rapid sample clean-up and extraction of pharmaceuticals from blood samples (whole blood, plasma and serum) during drug discovery. It also allows the disruption of drug binding to proteins. Blood samples from various species such as dogs, rats, mice, and humans show variations in their compositions, but often only a single bioanalytical method covers all these species. Protein precipitation denatures the protein and destroys its drug binding ability, depending on the binding mechanism

The most efficient precipitants for protein removal were zinc sulfate, acetonitrile, and trichloroacetic acid (at 2:1 volume of precipitant to plasma, the protein removal values were, respectively, 96, 92, and 91% with <1% RSD for n = 5)

The chosen precipitants functioned universally for all plasmas

Using acidic components exerted significant effects on ionization efficiency

Pure mobile phases with organic precipitants produced the largest ionization effects

Available both cartridge and 96-well plate formats. Both can be used with positive pressure processor, vacuum manifold, or centrifuge.

Protein crash kit has one protein crash plate, one collection plate and one cap mat

No solvent leakage during mixing, incubation and zero crosstalk

Technical Specifications

More Information
Product Type	Protein Crash and Protein Precipitate Filter
Capacity	1 mL
Design	Graded Frit
For use on	Rapid Sample Clean-Up and Extraction of Pharmaceuticals from Blood Samples
Number of Well Plate	96
Package Quantity	5 pkg

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